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Waters, Ph. Chesterfield classifieds Stack and Ann L. Research Triangle Park, NC July 9, Introduction to the Data Base There are currently more than test systems or bioassays for evaluating agents that induce genetic or related effects.


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McElheny Eds. The total data avt.

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MnI 1ian cells in vitro. B a P caused mutations and K in single studies in Tradescantia. It induced chron,soiTal 4 errat ion 4 y tatton in humen cells in vitro. Stack and M.

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Methods for the comparative analysis of the genetic activity profiles are given in Garrett et al. Research Triangle Park, NC July 9, Introduction to the Data Base There are currently more than test systems or bioassays for evaluating agents that induce genetic or related effects.

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The literature for these seven chemicals has been abstracted and reviewed in collaboration with EMCT for the Office of Pesticides and Toxic Substances. Table of contents. Cell transformation occurred in m. Beryllium thloride induced niitaticx in cultured thinese han ter cells.

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Chromosomal aberrations lAlen increased in bone marrow cells in Chinese hamster but not in rats in single stud. Tiai 1 u f CEI. If no volume is given, 2 ml top agar is assumed. Beryllium sulphate did rot induce mitotic reanbinatia in yeast in vitroor nutaticn in bacteria.


All dose values are plotted for each assay regardless of whether are positive or negative. If there were evidence of extreme toxicity, the next highest dose is used.

Benz a anthracene induced unscheduled DNA synthesis in rat hepatocytes but not in rat tracheal epithelial cells in a loojing study. Aidrin inhibited intercellulac c xu. Concentration varies depending Portugal pa whores the solubility of the compound.

Haroun, and H. Brady, P. L aberratfons h.

C - 0 Benz a anthracene did not induce aneuploidy in one study in Syrian hamster embryo Aleln in vitro. Benzene was not mutagenic to bacteria.

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Hsie, J. When all for a given assay are either positive or negative, the average of the responses is plotted as a solid line; when conflicting data are reported for the same assay i.

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A single dose tested with a negative result is considered equivalent to the HID. Short title. In a single study, it caused sister chromatid loooking in the bone marrow of Chinese hamsters treated at one dose level. Conflicting were reported for induction of gene mutation in in. Chr s.

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Norppa Mutagenicity of selected organic solvents, Scand. A complementary carcinogen data base was established by an IARC Working Group that met in March to evaluate the data on the carcinogexucity of these compounds to humans and to animals.

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The following assumptions are based on the physical properties of the tested agents. B a P caused unscheduled DNA synthesis and gene mutations in human cells in vitro. The offspring of treated female mice displayed somatic mutations in one study. S Plants.

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Health, 11 Suppl. The table of contents of this Act is as follows: Sec.

The following sums in this Act are appropriated, out of any money in the Treasury not otherwise appropriated, for the fiscal year ending September 30, LI, REM!!

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